Why testosterone matters for energy

There is a strong connection between testosterone and energy. In fact, one of the hormone’s primary functions is to keep your body’s energy engine running smoothly.

It does this in two main ways:

1. Mitochondrial function: Testosterone supports the function of mitochondria, the “powerhouses” of your cells responsible for energy production. When levels are optimal, mitochondria convert nutrients into energy more efficiently, helping you feel alert and capable throughout the day.
2. Red blood cell production: Testosterone supports the development of red blood cells, which deliver oxygen to your tissues. Better oxygen delivery translates to improved endurance and faster recovery, reducing that “hit a wall by 2 p.m.” feeling.

Low levels of testosterone can leave your body in “power-saving mode,” especially if you have a true deficiency. This can also impact brain chemicals like dopamine, a neurotransmitter that influences motivation and mental energy. While current research on testosterone and dopamine focuses largely on animal models, the link to human mental energy is well-observed clinically.

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Signs your energy slump could be low testosterone

We all have “off” days, but if you feel like you are constantly in “nap mode,” the cause might be more than just stress or a packed schedule. Low testosterone can quietly drain your physical and mental battery.

Here are signs that your persistent fatigue might be hormone-related:

• Chronic tiredness: You sleep, but still wake up feeling unrefreshed, as if you pulled an all-nighter.
• Low motivation: Activities you used to enjoy, like working out or pursuing hobbies, now feel like a chore.
• Reduced physical endurance: Workouts feel harder, recovery takes longer, and stamina drops for no obvious reason.
• Brain fog: Struggling to concentrate, remember details, or stay sharp.
• Mood changes: Increased irritability, low mood, or a sense that you are “not yourself.”

It is important not to self-diagnose. If you notice these symptoms, talk to a healthcare provider about hormonal health. They may recommend testing your testosterone levels to determine the best course of action.

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Can testosterone replacement therapy (TRT) help?

If blood tests confirm low testosterone, testosterone replacement therapy (TRT) might be a strategy to restore your levels. While not an instant fix, TRT can make a noticeable difference for men with diagnosed hypogonadism (a condition where the body doesn’t produce enough testosterone).

Studies show that TRT can help restore energy, mood, sense of well-being, and muscle strength in men with levels below the normal range. For those who respond well, effects may include better sleep and improved sexual function.

However, TRT is not recommended for men with normal testosterone levels. Boosting levels beyond what your body needs does not improve energy and can carry risks, such as:

• Skin changes: Acne or oily skin.
• Fluid retention: Bloating or puffiness.
• Polycythemia: Increased red blood cell counts, which can thicken blood and raise the risk of clots.
• Worsened sleep apnea: Existing sleep issues may get worse.
• Reduced fertility: Suppression of natural testosterone and sperm production.

TRT should always be administered under medical supervision, with regular lab work and follow-ups to ensure safety.

Natural ways to support testosterone and energy

You don’t necessarily need a prescription to support healthy testosterone levels. Sometimes, positive lifestyle changes are all you need to see significant improvements.

Here are research-backed, natural ways to increase testosterone and boost energy:

• Lift weights and get moving: Resistance training is one of the most effective natural testosterone boosters. High-intensity interval training (HIIT) also helps. Avoid overtraining, as it can have the opposite effect.
• Prioritize quality sleep: Your body produces most testosterone during deep sleep. Skimping on rest cuts levels short. Aim for 7–9 hours per night.
• Eat better: A nutrient-packed diet with zinc (pumpkin seeds, lentils, nuts), vitamin D (sunshine, fish, fortified foods), and healthy fats (avocados, olive oil) is essential. Avoid ultra-processed foods.
• Maintain a healthy weight: Excess body fat, especially around the midsection, is linked to lower testosterone. Losing even a few pounds can help restore optimal levels.
• Manage stress: Chronic stress raises cortisol, which suppresses testosterone. Prioritize mental health with meditation, deep breathing, or time outdoors.
• Limit alcohol and endocrine disruptors: Heavy drinking and exposure to chemicals like BPA in plastics can interfere with testosterone production.

By adopting these lifestyle tweaks, you might notice improvements in energy and overall well-being. If you experience sustained low energy, make an appointment to discuss your symptoms with a provider.

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Testosterone’s effect on energy: The takeaways

Testosterone isn’t the only factor in how energized you feel, but it certainly has a major influence. Here is what to remember:

• Major role: Testosterone supports mitochondrial function, oxygen delivery, and brain chemistry, all of which drive energy and motivation.
• Symptoms matter: Low testosterone is associated with fatigue, reduced endurance, and brain fog, but it is not the only cause of tiredness. Proper testing is key to diagnosis.
• Treatment options: TRT can be effective for men with clinically low T, but lifestyle strategies like strength training, sleep, and nutrition are powerful tools for everyone.

Ready to reclaim your energy? Chat with your provider if you suspect you may be experiencing low testosterone or need help navigating your symptoms.

noRxClinic offers at-home testing and email consultation to help you determine if your energy levels are linked to low testosterone.

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Sources (27)

1. Bachman, E., et al. (2014). Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC4022090/
2. Barrett-Connor, E., et al. (2008). The association of testosterone levels with overall sleep quality, sleep architecture, and sleep-disordered breathing. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC2453053/
3. Bassil, N., et al. (2009). The benefits and risks of testosterone replacement therapy: a review. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC2701485/
4. Bhasin, S., et al. (2018). Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline. PubMed. https://pubmed.ncbi.nlm.nih.gov/29562364/
5. Ceretti, E., et al. (2024). Consumption of Ultra-Processed Foods and Semen Quality in Healthy Young Men Living in Italy. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC11644553/
6. Corona, G., & Maggi, M. (2022). The role of testosterone in male sexual function. PubMed. https://pubmed.ncbi.nlm.nih.gov/35999483/
7. Donovan, A., & Wood, R. I. (2022). Effort-based decision making in response to high-dose androgens: role of dopamine receptors. PubMed. https://pubmed.ncbi.nlm.nih/36148834/
8. Fallah, A., et al. (2018). Zinc is an Essential Element for Male Fertility: A Review of Zn Roles in Men’s Health, Germination, Sperm Quality, and Fertilization. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC6010824/
9. Fink, J., et al. (2024). Management of Male Fertility in Hypogonadal Patients on Testosterone Replacement Therapy. PubMed. https://pubmed.ncbi.nlm.nih.gov/38399562/
10. Grech, A., et al. (2014). Adverse effects of testosterone replacement therapy: an update on the evidence and controversy. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC4212439/
11. Hayes, L. D., et al. (2017). Exercise training improves free testosterone in lifelong sedentary aging men. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC5510446/
12. Hirshkowitz, M., et al. (2015). National Sleep Foundation’s sleep time duration recommendations: methodology and results summary. PubMed. https://pubmed.ncbi.nlm.nih.gov/29073412/
13. Jung, H. J., & Shin, H. S. (2016). Effect of Testosterone Replacement Therapy on Cognitive Performance and Depression in Men with Testosterone Deficiency Syndrome. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC5209560/
14. Kim, S. D., & Cho, K. S. (2019). Obstructive Sleep Apnea and Testosterone Deficiency. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC6305865/
15. Lee, T. W., et al. (2023). Effects of Testosterone Replacement Therapy on Muscle Strength in Older Men with Low to Low-Normal Testosterone Levels: A Systematic Review and Meta-Analysis. PubMed. https://pubmed.ncbi.nlm.nih.gov/37494893/
16. Leproult, R., & Van Cauter, E. (2011). Effect of 1 week of sleep restriction on testosterone levels in young healthy men. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC4445839/
17. Monson, N. R., et al. (2023). Association Between Vitamin D Deficiency and Testosterone Levels in Adult Males: A Systematic Review. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC10518189/
18. Riachy, R., et al. (2020). Various Factors May Modulate the Effect of Exercise on Testosterone Levels in Men. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC7739287/
19. Yin, L., et al. (2021). Mitochondria in Sex Hormone-Induced Disorder of Energy Metabolism in Males and Females. Frontiers in Endocrinology. https://doi.org/10.3389/fendo.2021.749451
20. Ryu, D. Y., et al. (2023). Bisphenol-A disturbs hormonal levels and testis mitochondrial activity, reducing male fertility. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC10681812/
21. Su, M., et al. (2023). The Impact of Visceral Adiposity on Testosterone Levels in American Adult Men: A Cross-Sectional Analysis. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC10469406/
22. Sherman, G. D., et al. (2016). The interaction of testosterone and cortisol is associated with attained status in male executives. PubMed. https://pubmed.ncbi.nlm.nih.gov/26302434/
23. Shigehara, K., et al. (2015). Effects of testosterone replacement therapy on nocturia and quality of life in men with hypogonadism: a subanalysis of a previous prospective randomized controlled study in Japan. PubMed. https://pubmed.ncbi.nlm.nih.gov/26075538/
24. Smith, S. J., et al. (2023). The effects of alcohol on testosterone synthesis in men: a review. PubMed. https://pubmed.ncbi.nlm.nih.gov/36880700/
25. Straftis, A. A., & Gray, P. B. (2019). Sex, Energy, Well-Being and Low Testosterone: An Exploratory Survey of U.S. Men’s Experiences on Prescription Testosterone. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC6765788/
26. Whittaker, J., & Wu, K. (2021). Low-fat diets and testosterone in men: Systematic review and meta-analysis of intervention studies. PubMed. https://pubmed.ncbi.nlm.nih.gov/33741447/
27. Zitzmann, M. (2020). Testosterone, mood, behaviour and quality of life. PubMed. https://pubmed.ncbi.nlm.nih.gov/32657051/